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. Author manuscript; available in PMC: 2023 Jun 2.
Published in final edited form as: Cancer Discov. 2022 Dec 2;12(12):2930–2953. doi: 10.1158/2159-8290.CD-21-0865

Fig. 5. Loss of EpiDrivers induces multipotency.

Fig. 5.

A, Percent of GFP+ EPCAMhigh CD49fmid luminal cells at different time points after Ad-K5-Cre injection into mammary epithelium of mice with the indicated genotype. B, Representative FACS plot at 4 weeks post injection with Ad-K5-Cre. C, Whole-mount image of mammary glands 4 weeks and 7.5 weeks post Ad-K5-Cre injection showing K14+/K8- (empty arrows) as well as K14+/K8+ double-positive and K14-/K8+ GFP+ lineage-traced cells (filled arrows). Scale bar = 50 μm. D and E, Tumor-free survival of Pik3caH1047R;Kdm6afl/fl versus Pik3caH1047R after intraductal injection of Ad-K5-Cre (D) and Ad-K8-Cre (E).