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. 2022 Dec 15;11:e82556. doi: 10.7554/eLife.82556

Figure 2. Acetylserotonin O-methyltransferase (ASMT) isoform comparison.

Figure 2.

Comparison of predicted structures of ASMT, showing the 373aa isoform from Matched Annotation from NCBI and EMBL-EBI (MANE) (CHS.57426.2, RefSeq NM_001171038.2, GENCODE ENST00000381241.9) on the left, and a 345aa alternate isoform from Comprehensive Human Expressed SequenceS (CHESS) (CHS.57426.4, GENCODE ENST00000381229.9) on the right. The CHESS 345aa isoform closely matches the experimentally determined X-ray crystal structure of the biologically active protein (Botros et al., 2013), shown at the bottom.