Figure 5. TXNDC8 isoform comparison.

Predicted protein structures for seven distinct human isoforms of thioredoxin domain-containing protein 8 (TXNDC8), as well as the primary cattle transcript and a novel mouse transcript. Alternate human isoforms 4, 9, and 12 (right side of figure) lack multiple canonical thioredoxin structures and thus appear non-functional. Several canonical protein motifs are missing or altered in the predicted structure of the Matched Annotation from NCBI and EMBL-EBI (MANE) transcript (top center). In contrast, the alternate human transcript 14 matches cattle and mouse to within 0.8 Å. Human transcript CHS.56446.14 is colored solid dark blue because every amino acid residue scores a predicted local distance difference test (pLDDT) above 90.