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. 2022 Dec 15;11:e82556. doi: 10.7554/eLife.82556

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© 2022, Sommer et al

This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.

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Figure 6. — Comparison of predicted structures for interleukin 36 beta (IL36B) for the Matched Annotation from NCBI and EMBL-EBI (MANE) isoform (CHS.30565.1, RefSeq NM_014438.5, GENCODE ENST00000259213.9) and an alternate isoform from Comprehensive Human Expressed SequenceS (CHESS) and RefSeq (CHS.30565.4, RefSeq XM_011510962.1). The highly conserved protein sequence of the alternate human isoform achieves a very high predicted local distance difference test (pLDDT) score of 93.0, versus the MANE isoform’s much lower pLDDT of 50.2.