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VEGFB isoforms VEGFB-186 (a) and VEGFB-167 (b). The inclusion of a heparin binding domain in VEGFB-167 results in sequestration to the cell surface while VEGFB-186 remains freely soluble. Relying solely on predicted local distance difference test (pLDDT) comparisons in this case would be misleading, as both isoforms represent well-understood functional protein products.
