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. Author manuscript; available in PMC: 2023 Jan 4.
Published in final edited form as: Nat Struct Mol Biol. 2021 Feb 8;28(3):240–248. doi: 10.1038/s41594-020-00551-9

Extended Data Fig. 2. Comparison of human SPTLCs and their bacterial homolog.

Extended Data Fig. 2

(a) Structure of the cytosolic domains of human SPTLC1 and SPTLC2. For clarity, only one local dimer is shown. (b) Structure of the serine palmitoyltransferase from Sphingomonas paucimobilis (SpSPT, PDB 2JG2). (c) Overlay of the human SPTLCs and their bacterial homolog. (d) Structural comparison of human SPTLCs and their bacterial homolog in the active site.