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. 2023 Jan 4;40(1):27–46. doi: 10.1007/s11095-022-03460-2

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Fig. 13 — Systematic derivatization of YSK12-C4. The YSK12-C4 is divided into 3 sections, an ionizable head group, distal, and proximal side of hydrophobic tails. Each part of the YSK12-C4 was derivatized to assess structure–activity relationship. The notation for the ionizable lipids used in this study are abbreviated as cationic lipid (CL), followed by the order of the number of carbons in the head group (1 to 15), distal (A to H) and proximal side (6 to 10) of the hydrophobic tails.