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Minimum Temperature Required for Formation of Temporarily Stable Liposomes Containing DOTAP or DOTAP Analogs
| Lipid | Phase transition temperature (Tc) | Without helper lipid | With Dope (1:1) |
|---|---|---|---|
| DOTAP | < 5°C | RT | RT |
| DSTAP | 62.9°C | 55°C | 50°C |
| DPTAP | 52.8°C | 50°C | 35°C |
| DMTAP | 39.1°C | 40°C | RT |
| LPTAP | 43.1°C | 35°C | RT |
| DLTAP | 24.9°C | 25°C | RT |
