TABLE 1.
Summary of inhibitory synaptic phenotypes and behavior following functional manipulations of neurexins in mice.
| Gene | Cell type | Phenotype | References |
| Nrxn 1, 2, 3 conditional triple KO | PV-Cre | Decreased n and PV-IPSCs in mPFC (sex not specified) | Chen et al., 2017 |
| SST-Cre | Decreased Pr and SOM-IPSCs in mPFC (sex not specified) | Chen et al., 2017 | |
| vGlut3-Cre | Decreased Pr, connectivity, and vGlut3-IPSCs in CA1 (male and female) | Uchigashima et al., 2020a | |
| Nrxn3 conditional KO | Regional KO by AAV-Cre delivery | No change to IPSCs in hippocampal culture, reduction of IPSCs in olfactory bulb culture and granule cell-synapses in ex-vivo olfactory bulb slice | Aoto et al., 2015 |
| vGAT-Cre | Lethal-mice die at birth | Keum et al., 2018 | |
| PV-Cre | Increased Pr and PV-IPSCs in female subiculum, decreased n, q, and PV-IPSCs in male subiculum Behavior: No change in observational fear |
Keum et al., 2018; Boxer et al., 2021 | |
| SST-Cre | Decreased Pr and SOM-IPSCs in ACC (males) Behavior: increased observational fear |
Keum et al., 2018 | |
| Nrxn3 SS5 KO | Constitutive | Reduced IPSCs from IML synapses (putative CCKs), reduced SOM-IPSCs, no effect on PV-IPSCs in DG | Hauser et al., 2022 |
| Nrxn 1, 3 SS4 exclusion, conditional | PV-Cre | No change to PV synapse puncta density or synapse ultrastructure in CA1 Behavior: Impaired short-term memory in novel object recognition task |
Nguyen T. -M. et al., 2016 |
| Nrxn1α KO | Constitutive | No change to CA1 mini or spontaneous IPSCs Behavior: Increased grooming, enhanced rotarod motor learning, impaired nest building, impaired pre-pulse inhibition Behavior: reduced social investigation (M and F), increased aggression (males) Decreased IPSC amplitude and inhibitory connectivity in BLA Behavior: Reduced fear expression |
Etherton et al., 2009; Grayton et al., 2013; Asede et al., 2020 |
ACC, anterior cingulate cortex; BLA, basal lateral amygdala; CA1, cornu ammonis 1 (hippocampus); CCK, cholecystokinin; DG, dentate gyrus; IML, inner molecular layer; IPSC, inhibitory post-synaptic current; KO, knock-out; mPFC, medial prefrontal cortex; n, synapse number; Pr, release probability; PV-Cre, Parvalbumin-IRES-Cre mouse line; q, quantal size; SOM, somatostatin; SS, splice site; SST-Cre, somatostatin-IRES-Cre mouse line; vGlut3-Cre, vesicular glutamate transporter 3 Cre mouse line.