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Illustration of the TRAIL/DOX-Gelipo design, showing the HA crosslinked outer shell encapsulating DOX and TRAIL, and the proposed multistage delivery of TRAIL to the cell surface and DOX to the nucleus as an example of CD44 liposomal targeting of breast cancer. Reprinted with permission from Ref. [162]. Copyright 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
