Fig. 13.

Examples of MUC1 liposomal targeting of breast cancer. (A) In vivo multispectral optoacoustic tomography imaging of 4T1 murine breast tumor models after intravenous injections of either the non-targeted or targeted liposomes. Although both non-targeted and targeted liposomes accumulated in the tumors over time, the targeted liposomes accumulated more quickly and along the periphery of the tumors (rather than penetrating at the center). Adapted and reprinted with permission from Ref. [201]. Copyright 2015 Elsevier. (B) In vitro cellular uptake of h-MUC1 gold nanocage liposomes (h-MCU1 AuNG-Lip) in MCF-7 (MUC1 positive cells) over time. In vivo time-dependent fluorescence revealing the tumor accumulation of the h-MUC1-functionalized liposomes over time. Adapted and reprinted with permission from Ref. [202]. Copyright 2016 Elsevier.