Fig. 14.

Examples of estrogen receptor liposomal targeting for breast cancer. (A) Imaging of MCF-7 tumor-bearing mice and organs after a tail vein injection of either non-targeted or E1-functionalized DiR-encapsulated long-circulating liposomes (ES-SSL-DiR). Accumulation of the ES-SSL-DiR liposomes could be seen in the liver, spleen, kidneys and the tumor site within 1 h of administration peaking at 12 h. Adapted and reprinted with permission from Ref. [211]. Copyright 2019 Dovepress. (B) Schematic of the synthesis and internalization process of the DOX-encapsulating synergistic targeted liposome carrier system (SELS DOX). Reprinted with permission from Ref. [209]. Copyright 2019 Royal Society of Chemistry.