Fig. 16.

Example of a dual-ligand liposomal system targeting both MDA-MB-231BR cells and their mitochondria via BRBP1-TAT-KLA-functionalized liposomes. The illustration demonstrates how the targeted liposomes are expected to bypass through the blood-brain barrier (BBB) to accumulate in brain metastatic breast cancer tumors to delivery EMT-associated TWF1 gene therapy. Reprinted with permission from Ref. [362]. Copyright 2021 American Chemical Society.