Fig. 17.

Example of a dual-ligand liposomal system targeting both P-selectin via the CDAEWVDVS peptide and the αvβ3 integrin receptor via the cRGD peptide in metastatic breast cancer. Bioluminescence imaging (BLI) showed mice before and after resection of the primary tumor and in vivo fluorescence molecular tomography imaging showed the spread and location of the metastatic cells visualized using the dual-targeted liposomes. Adapted and reprinted with permission from Ref. [366]. Copyright 2015 American Chemical Society.