Fig. 3. Strategies for modeling neurodevelopmental perturbations in rodents.

A When a risk factor is present in a specific cell lineage in the human brain (in red, top), but the expression is broader in the rodent brain (in red, bottom), utilization of cell type-specific transgenics can restrict risk factor analysis to the cell lineage relevant for human brain (in blue). B When the expression of a risk factor is broader in the human brain (in red, top) than in an animal model of interest (in red, bottom), the model can be utilized to target specific cell lineages or developmental periods. C To model an interplay of two risk factors (in red, top), transgenic models with intersectional gene expression can be utilized (bottom, blue and yellow are individual transgenic lines, the intersection is in green).