Table 2.
Examples of ISCs-specific interventions that extend lifespan in Drosophila.
| “Hallmarks of aging” | Intervention | Reference |
|---|---|---|
| Loss of Proteostasis | PERK downregulation | [95] |
| Hsp68 overexpression | [86] | |
| Deregulated Nutrient-Sensing | Inhibition of JNK signaling | [86] |
| Overexpression of Jafrac1 | [86] | |
| Downregulation of lnR | [86] | |
| Downregulation of Dp110 | [86] | |
| Downregulation of Akt | [86] | |
| Downregulation of dMfn | [96] | |
| Activation of Drp1 | [96] | |
| Downregulation of Bsk and BskD | [86] | |
| Mitochondrial Dysfunction | Overexpression of dPGC-1 | [97] |
| Overexpression of Ndi1 | [98] | |
| Altered Intercellular Communication | Activation of Kif1a | [98] |
| PGRP-SC2 overexpression | [99] | |
| Overexpression of Ssk | [100] | |
| Stem Cell Exhaustion | Overexpression of dPGC-1 | [97] |
The table summarizes genetic interventions that have been shown to be sufficient to extend lifespan in D. melanogaster when targeted to intestinal stem cells (ISCs).