Extended Data Fig. 9. ATACseq analysis of the different senescent cell types throughout life.

a) Differential ATAC-seq peaks for Sen vs NSen SCs, FAPs, and MCs from old mice at 3 and 7 d.p.i. Left: log₂FC plotted against log₂-transformed average peak intensity (peak score); the green line shows the position of each average peak score on the log₂FC axis; the number of peaks with log₂FC >1 or ≤1 is indicated. b) Normalized ATAC-seq signal profiles in the indicated gene regions from Sen vs NSen SCs, FAPs, and MCs from young and old mice at 7 d.p.i. c) Heatmap representing transcription factors and co-regulators of transcription enriched in at least 11/12 comparisons for Sen vs NSen with average Trust score > 1 (see Methods). Colour codes reflect the activity predicted based on analysis of differential expression (DESeq2), upstream regulators analysis (QIAGEN’s IPA) and motif enrichment analysis in RNA-seq and ATAC-seq data.

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