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. 2022 Dec 14;613(7942):120–129. doi: 10.1038/s41586-022-05534-y

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© The Author(s) 2022, corrected publication 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 8 — a) Images of LYVE1+ (green; top) and IBA1+ (magenta) LYVE1+ macrophages (bottom) in human ALSP and age-matched unaffected control frontal white matter. Scale bar, 50 μm. b) Magnified images from dotted outlines in (A) of IBA1+ LYVE1+ perivascular macrophages in human ALSP and unaffected age-matched control frontal white matter. Scale bar, 50 μm. c) Mean IBA1+ LYVE1+ cells/mm² ± s.e.m. in ALSP and unaffected control. n = 3 cases/group. P = 0.1000, Mann Whitney test. d) Mean proportion of IBA1+ cells which are perivascular macrophages (LYVE1+; grey) or microglia (LYVE1-; black) ± s.e.m. in ALSP and unaffected control. n = 3 cases/group. **P = 0.0034, 1-way ANOVA with Tukey’s multiple comparisons test. e) Mean number of myelinated axons/axon diameter bin in unaffected control and ALSP patients. n = 2 cases/group. f) Mean inner tongue thickness (µm)/axon diameter bin in Control and ALSP patients. n = 2 cases/group. g) Mean myelin thickness (µm)/axon diameter bin in unaffected control and ALSP patients. n = 2 cases/group.

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