Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Dec 14;613(7942):120–129. doi: 10.1038/s41586-022-05534-y

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022, corrected publication 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Extended Data Fig. 2 — a) Mean pixel intensity of MAG and MBP ± s.e.m. in corpus callosum at 1 month of age. Non-significant, P = 0.6482 and 0.1097 respectively, 2-tailed unpaired Student’s t-test. n = 5 mice/group. b) Images of CNPase, MOG, and PLP (white) in corpus callosum at 1 month of age. Scale bar, 75 μm. c) Mean pixel intensity of CNPase, MOG, and PLP ± s.e.m. in corpus callosum at 1 month of age. Non-significant, P = 0.9758, 0.5699 and 0.4551 respectively, 2-tailed unpaired Student’s t-test. n = 5 mice/group. d) Images of MBP (magenta) and MAG (green) in cerebellum at 1 month of age. Scale bar, 75 µm. e) Mean pixel intensity of MBP and MAG ± s.e.m. in cerebellum at 1 month of age. Non-significant, P = 0.3067 and 0.5462 respectively, 2-tailed unpaired Student’s t-test. n = 5 mice/group. f) Images of neurofilament (NF; green) in corpus callosum at 1 month of age. Scale bar, 75 μm. g) Mean pixel intensity of NF ± s.e.m. in corpus callosum at 1 month of age. Non-significant, P = 0.4623, 2-tailed unpaired Student’s t-test. n = 5 FIRE^+/+ and 6 FIRE^Δ/Δ. h) Images of axonal spheroids in corpus callosum of FIRE^Δ/Δ mice at 3-4 months and 6 months, indicated with arrows. Scale bar, 2 μm and 1 µm, respectively.

Source data