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. 2022 Dec 5;17(1):173–187. doi: 10.1002/1878-0261.13345

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© 2022 The Authors. Molecular Oncology published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Fig. 7 — In silico analyses for potential biological functions of screened interactions. The functional enrichment analyses for co‐expressed genes of integrative score. (A) 16 significant KEGG pathways. (B) Top 20 significant biological process pathways. (C) Top 20 significant cellular component pathways. (D) Top 20 significant molecular function pathways. (E) Gene network of screened genes and immune checkpoint genes, which constructed by GeneMINIA. The blue circles represents the first neighbours of the screened genes, which suggests direct functional connections. (F) Correlations between proportions of immune cells and integrative score.