Table 3:

Most Frequently Observed Treatment Related Adverse Events

	Prior Chemotherapy Exposure		Chemotherapy Naïve
Dose Level	100mg	200mg	100mg	200mg	300mg
Patients	10	5	3	7	5
Max Grade 2 TRAE
Hematologic
Anemia	1 (10%)	1 (20%)	-	1 (14%)	1 (20%)
Thrombocytopenia	2 (20%)	1 (20%)	-	2 (29%)	-
Neutropenia	2 (20%)	1 (20%)	-	-	-
Gastrointestinal
Diarrhea	2 (20%)	1 (20%)	-	3 (43%)	3 (60%)
Constipation	3 (30%)	-	-	2 (29%)	3 (60%)
Dry Mouth	1 (10%)	-	-	2 (29%)	1 (20%)
Nausea	4 (40%)	4 (80%)	1 (33%)	5 (71%)	3 (60%)
Vomiting	-	1 (20%)		2 (29%)	1 (20%)
Other
Hypertension	2 (20%)	-	1 (33%)	-	-
Fatigue	4 (40%)	3 (60%)	-	3 (43%)	5 (100%)
Decrease Appetite	3 (30%)	1 (20%)	2 ( 67%)	2 (29%)	-
Max Grade 4 TRAE
Hematologic
Anemia	-	1 (20%)	-	1 (14%)	1 (20%)
Thrombocytopenia	-	1 (20%)	-	1 (14%)	-
Neutropenia	-	2 (40%)	-	-	1 (20%)
Gastrointestinal
Nausea	-	-	-	-	1 (20%)
Other
Hypertension	1 (10%)	1 (20%)	1 (33%)	-	1 (20%)