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. 2022 Oct 3;22(1):102–111. doi: 10.1158/1535-7163.MCT-22-0375

Figure 1.

Figure 1. Multiscale pharmacokinetics of ADCs. A, ADCs in systemic circulation distribute to both tumor and healthy tissue, where they can bind their target and release the payload. In addition, deconjugation in the systemic circulation releases payload, lowering the DAR. B, Within the tumor, ADCs extravasate, diffuse through the tissue, bind their target, internalize, and release the payload via hydrolysis or protease cleavage for CL2A and CL2E linkers, respectively. Linker hydrolysis can also occur extracellularly, and released payload can diffuse to nearby cells (bystander effect).

Multiscale pharmacokinetics of ADCs. A, ADCs in systemic circulation distribute to both tumor and healthy tissue, where they can bind their target and release the payload. In addition, deconjugation in the systemic circulation releases payload, lowering the DAR. B, Within the tumor, ADCs extravasate, diffuse through the tissue, bind their target, internalize, and release the payload via hydrolysis or protease cleavage for CL2A and CL2E linkers, respectively. Linker hydrolysis can also occur extracellularly, and released payload can diffuse to nearby cells (bystander effect).