Table 3.

Multivariable analysis showing an independent association between RHI and occurrence of clinical events.

Variable	HR (95% CI)	P value
Age ≥ 65 years	2.06 (0.74–5.71)	0.162
Female sex	0.68 (0.23–2.05)	0.504
Body mass index ≥ 25 kg/m2	0.48 (0.18–1.27)	0.142
Hypertension	0.86 (0.27–2.72)	0.800
Diabetes mellitus	1.72 (0.63–4.69)	0.283
Estimated GFR < 60 mL/min/1.73 m2	1.44 (0.52–3.96)	0.479
Left ventricular ejection fraction < 50%	0.30 (0.05–1.62)	0.162
RAS blockers	1.83 (0.45–7.45)	0.396
RHI < 1.48	14.09 (3.61–54.99)	< 0.001

RHI reactive hyperemic index; HR hazard ratio; CI confidence interval; GFR glomerular filtration rate; RAS renin-angiotensin system.