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. 2022 Jul 15;44(1):234–243. doi: 10.1038/s41401-022-00949-9

Fig. 1. Screening to identify compounds selectively inhibiting IRE1α-XBP1s.

Fig. 1

a Schematic showing the screening pipeline to identify prioritized compounds that selectively inhibit IRE1α. This pipeline includes identification of compounds that inhibit the XBP1-luc reporter, removal of compounds that inhibit the CHOP-luc reporter and assay of IRE1α RNase activity. b Chemical structures of five final prioritized IRE1α-XBP1s inhibitors identified. c RNase activities measured after indicated concentrations of the five final prioritized inhibitors were added to purified recombinant human IRE1α protein for 1 h.