Table 1.

RNase IC₅₀, ROS production, and predicted binding energies of TXF and its derivatives for IRE1α.

Compound	RNase IC50 (μM, 95% CI)	ROS ratio to DMSO (0.5 μM, average ± SD)	Binding energy (kcal/mol)
TXF	0.226 (0.188–0.274)	22.8 ± 0.950	−5.05
WNN1229-D011	1.04 (0.901–1.20)	15.7 ± 1.38	−5.17
WNN1288-A005	1.58 (0.993–2.50)	16. 6 ± 1.75	−3.45
WNN1229-E002	2.40 (2.01–2.86)	11.9 ± 0.450	−3.83
WNN2363-H008	2.98 (2.27–3.92)	13.6 ± 2.50	−3.70