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. Author manuscript; available in PMC: 2024 Jan 1.
Published in final edited form as: Adv Drug Deliv Rev. 2022 Nov 26;192:114635. doi: 10.1016/j.addr.2022.114635

Figure 5.

Figure 5.

Schematic illustrations of (a) differential organ distribution of O- and N-series LNPs and (b) interaction of LNPs with proteins in the blood vessel. Quantification of the percentage of total proteins of the top three protein components in the protein corona of (c) the O-series LNPs (306-O12B) and (d) the N-series LNPs (306-N16B). Top 20 most abundant corona proteins based on (e) their calculated molecular weight, (f) isoelectric point, and (g) biological function. Reprinted from [215] with permission.