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. 2022 Jun 2;44(1):145–156. doi: 10.1038/s41401-022-00921-7

Fig. 2. CAPE treatment inhibits the BSH activity, regulates bile acid composition and inhibits intestinal FXR signaling.

Fig. 2

C57BL/6 mice fed a HFD treated with vehicle and CAPE for 8 weeks (n = 5). BSH enzymatic activity in the cecum contents as measured by the percentage of d5-TCDCA remaining a and the d5-CDCA generation rate b in the BSH incubations. The concentration (c) and percentage (d) of the individual taurine-conjugated BAs in ileum. mRNA levels of FXR target genes (Fxr, Fgf15 and Shp) and Gcg in the ileum. f mRNA levels of FXR target genes (Fxr, and Shp) in liver. g mRNA levels for ceramide synthesis-related enzymes in the ileum. Data are presented as the means ± SD. Two-tailed Student’s t-test: *P < 0.05 and **P < 0.01.