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. 2022 Jun 20;72(1):73–85. doi: 10.1007/s00262-022-03226-0

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Figure. 1 — Accumulation of MDSCs in cervical cancer patients. a Flow cytometry analysis of PMN-MDSCs in peripheral blood from patients with benign or malignant tumors. Statistical analysis of the frequencies of PMN-MDSCs as a percentage of the mononuclear cells (MCs) population. b Flow cytometry analysis of M-MDSCs in peripheral blood from patients with benign or malignant tumors. Statistical analysis of the frequencies of M-MDSCs as a percentage of the MCs population. c Flow cytometry analysis of the frequency of PMN-MDSCs in the peripheral blood of patients with cervical cancer before and 5 days after surgery. Statistical analysis of the frequencies of PMN-MDSCs as a percentage of the MCs population. d Flow cytometry analysis of the frequency of M-MDSCs in the peripheral blood of patients with cervical cancer before and 5 days after surgery. Statistical analysis of the frequencies of M-MDSCs as a percentage of the MCs population. e–g ELISA analysis of the concentrations of IDO, INOS and Arg-1 in the peripheral blood of patients with either malignant or benign cervical tumors. Each point corresponds to an individual patient. Lines indicate the 25th to 75th percentiles. Horizontal lines represent the median value. Data were analyzed using Student’s t test and are expressed as the mean ± SD. Symbols represent statistical significance (*p < 0.05)