Table 4.

Direct and estimated uptake of hypothetical cancer screening tests

	Overall	Class 1: find my cancer (43%)	Class 2: sensitivity/specificity trade-off (41%)	Class 3: wary of screening; particularly false results (16%)
Direct screening preferences
Screening A (50 types of cancer tested, 55.2% sensitivity, 99.3% specificity, 11% cancer type unknown)	1223 (72%)	580 (79%)	578 (83%)	65 (24%)
No screening	477 (28%)	151 (21%)	115 (17%)	211 (76%)

		Class 1: find my cancer (43%) % [95% CI]	Class 2: sensitivity/specificity trade-off (41%) % [95% CI]	Class 3: wary of screening; particularly false results (16%) % [95% CI]
Estimated uptake
Hypothetical MCED test (50 types of cancer tested, 55.2% sensitivity, 99.3% specificity, 10.5% cancer type unknown)		62.0% [52.2–71.8]	71.9% [67.1–76.7]	52.4% [40.5–64.4]
Hypothetical single-cancer blood test screening (1 type of cancer tested, 88% sensitivity, 87% specificity, 0% cancer type unknown)		38.0% [28.2–47.8]	28.1% [23.3–32.9]	47.6% [35.6–59.5]

CI confidence interval, MCED multi-cancer early detection