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. 2022 Nov 30;91(1):53–66. doi: 10.1007/s00280-022-04497-1

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — Platinums and anthracyclines in a concentration-dependent way differently alter the differentiation process and functions of both macrophages and dendritic cells. In order to better illustrate our observations we summarized our results in heat maps. Macrophages and dendritic cells are both sensitive to chemotherapeutic agents but the chemicals have different effects on APC differentiation. Additionally, platinums and anthracyclins differently alter the phenotypical and functional properties of dendritic cells and macrophages