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. 2022 Jul 25;270(1):44–56. doi: 10.1007/s00415-022-11252-2

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© The Author(s) 2022

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Fig. 2 — Correlation analyses with disease duration and improvement of ataxia with AL treatment. Before treatment (PET A) the duration of cerebellar symptoms was found to be positively correlated with the glucose metabolism (the longer the symptoms lasted, the higher the metabolism) in the central sulcus region bilaterally, including primary and secondary somatosensory as well as primary/premotor cortex areas (juxtapositional lobule cortex; formally supplementary motor cortex). B The improvement of ataxia with AL treatment (decreasing SARA score) was correlated with a decrease in glucose metabolism between PET A and B (indicated in blue) in bilateral parts of the visual cortex and the superior/middle temporal gyrus (secondary vestibular network area), as well as with an increase in glucose metabolism (indicated in red) in the midline left cerebellum and the right posterior insula region (multisensory vestibular)