Table 1.
MicroCT analysis of femoral subchondral bone from DMM-operated and un-operated knee joints of mice subjected to vehicle (n = 10) or probiotics (n = 11) treatment
| DMM knee | Un-operated knee | |||
|---|---|---|---|---|
| mCT parameter | Vehicle | Probiotics | Vehicle | Probiotics |
| BV/TV (%) | 28.4 ± 1.1 | 32.8 ± 1.0* | 29.2 ± 1.0 | 32.4 ± 0.7* |
| Tb.Th (μm) | 57.0 ± 1.2 | 63.2 ± 1.2*** | 57.7 ± 1.2 | 62.6 ± 0.7*** |
| Tb.N (1/mm) | 5.0 ± 0.1 | 5.2 ± 0.1 | 5.1 ± 0.1 | 5.2 ± 0.1 |
| Tb.Sp (μm) | 183.1 ± 5.3 | 179.7 ± 3.7 | 187.0 ± 3.0 | 180.8 ± 3.1 |
| Tb.Pf (1/mm) | 7.2 ± 0.6 | 4.6 ± 0.6** | 6.0 ± 0.7 | 4.0 ± 0.6* |
| Medial plate thickness (μm) | 95.5 ± 3.4 | 101.6 ± 2.8 | 93.8 ± 4.0 | 95.6 ± 1.7 |
| Lateral plate thickness (μm) | 114.4 ± 2.8 | 125.4 ± 2.4** | 118.8 ± 2.5 | 111.3 ± 4.0 |
mCT microCT, BV/TV trabecular bone volume, Tb.Th trabecular thickness, Tb.N trabecular number, Tb.Sp trabecular separation, Tb.Pf trabecular pattern factor. Values are mean ± SEM. *p < 0.05; **p < 0.01; ***p < 0.05 vs. vehicle