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. 2023 Jan 4;6:8. doi: 10.1038/s42003-022-04404-7

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Principal component analysis of lipids detected in the positive (+) ion mode and negative (−) ion mode of male WT, Tmem135 TG (TG), and Tmem135^{FUN025/FUN025} (FUN025) livers, retinas, hearts, and plasmas based on log10 lipid concentrations. Number in parentheses represent the N of independent mouse samples per genotype used in the experiment. b Pie graphs of docosahexaenoic acid (DHA, C22:6n3)-containing lipids that were significantly upregulated (dark green) or downregulated (medium green) as well as unchanged (light green) in Tmem135^{FUN025/FUN025} tissues compared to WT. Numbers denote the total of lipids within the category. All altered lipid species can be found in Supplementary Tables 6–9. Significance was determined by one-way ANOVA with post hoc Tukey’s test between WT and Tmem135^{FUN025/FUN025} livers (P < 0.05).