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. 2023 Jan 4;14:61. doi: 10.1038/s41467-022-35725-0

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Domain organization of GSDMB and IpaH7.8. NTD N-terminal domain, CTD C-terminal domain, LRR leucine-rich repeat domain, NEL novel E3 ligase domain. b Superimposed gel-filtration profiles of GSDMB, LRR and GSDMB-LRR complex. Shown on the bottom is SDS-PAGE analysis of the elution fractions corresponding to the GSDMB-LRR complex. c ITC-based measurements quantifying the binding affinities between GSDMB and IpaH7.8. ND no detectable binding. d ITC analysis of IpaH7.8 binding to CTD of GSDMB. ND no detectable binding. Source data are provided as a Source Data file.