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. 2023 Jan 4;14:61. doi: 10.1038/s41467-022-35725-0

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Cartoon representation of the GSDMB-LRR structure. The LRR units are indicated by numbers. The color scheme is the same as in Fig. 1a. b Overall structure of GSDMB. The NTD and CTD are colored green and light blue, respectively. The inter-domain linker is colored pink. c Close-up view of the intramolecular interactions involved in the NTD-CTD interface. Polar interactions are indicated by yellow dashed lines.