Table 1.
Physical and laboratory measurements at baseline.
| Parameter | Sitagliptin | Control | P-value* | ||
|---|---|---|---|---|---|
| n | Mean (SD) | n | Mean (SD) | ||
| Age (year) | 82 | 70.6 (3.9) | 76 | 71.9 (4.4) | 0.051 |
| BMI (kg/m2) | 69 | 24.9 (3.5) | 63 | 24.7 (3.9) | 0.73 |
| SBP (mmHg) | 77 | 131 (14) | 71 | 132 (14) | 0.73 |
| DBP (mmHg) | 77 | 73 (11) | 71 | 70 (9) | 0.08 |
| FPG (mg/dL) | 75 | 174 (54) | 70 | 161 (53) | 0.17 |
| GA (%) | 82 | 22.1 (3.8) | 76 | 21.4 (3.0) | 0.20 |
| HbA1c (%) | 82 | 7.8 (0.9) | 76 | 7.6 (0.5) | 0.08 |
| Insulin (μU/mL) | 75 | 9.6 (6.6) | 70 | 8.1 (6.2) | 0.16 |
| Proinsulin (pmol/L) | 74 | 33.9 (26.3) | 69 | 28.5 (19.5) | 0.17 |
| Cr (mg/dL) | 82 | 0.79 (0.21) | 76 | 0.81 (0.23) | 0.49 |
| CysC (mg/L) | 82 | 1.00 (0.23) | 76 | 1.02 (0.23) | 0.61 |
| Cr-based eGFR | 82 | 70 (17) | 76 | 67 (16) | 0.33 |
| CysC-based eGFR | 82 | 72 (18) | 76 | 70 (15) | 0.41 |
| uACR (mg/g Cr) | 82 | 176 (512) | 76 | 114 (246) | 0.33 |
| T-C (mg/dL) | 82 | 192 (43) | 76 | 188 (37) | 0.53 |
| HDL-C (mg/dL) | 82 | 55 (15) | 76 | 54 (13) | 0.79 |
| LDL-C (mg/dL) | 74 | 111 (35) | 69 | 108 (34) | 0.62 |
| Non-HDL-C | 82 | 138 (41) | 76 | 134 (37) | 0.58 |
| Triglycerides (mg/dL) | 75 | 141 (83) | 70 | 142 (115) | 0.98 |
*Between-group differences based on unpaired t-test. BMI body mass index, Cr creatinine, CysC cystatin C, DBP diastolic blood pressure, eGFR estimated glomerular filtration rate (mL/min/1.73 m2), FPG fasting plasma glucose, GA glycated albumin, HDL-C HDL cholesterol, LDL-C LDL cholesterol, Non-HDL-C non-HDL cholesterol, SBP systolic blood pressure, T-C total cholesterol, uACR urinary albumin-creatinine ratio.