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. 2022 Dec 22;16:1099348. doi: 10.3389/fnana.2022.1099348

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Copyright © 2022 Pfeiffer and Jones.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Metabolic and receptor changes phase 1 remodeling in 3mo P347L rabbit: (A) top panel: 3-channel composite of metabolites taurine, glutamine and glutamate. Lower panels: individual metabolites taurine and glutamine. Arrows indicate neighboring Müller cells. (B) Theme map of cell types in a horizontal section of retina identified based on ionotropic glutamate receptor function. Phase 2 remodeling in 2yo P347L rabbit: (C) top panel: 3-channel composite of metabolites taurine, glutamine and glutamate. Lower panels: individual metabolites taurine and glutamine. Arrows indicate neighboring Müller cells. (D) Theme map of cell types in a horizontal section of retina identified based on ionotropic glutamate receptor function. Phase 3 remodeling in 4yo P347L rabbit: (E) top panel: 3-channel composite of metabolites taurine, glutamine, and glutamate. Lower panels: individual metabolites taurine and glutamine. Arrows indicate Müller cell devoid of taurine and containing reduced glutamine. Bracket indicates region of Müller cells with varying levels of small molecules.