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. 2022 Dec 22;16:1099348. doi: 10.3389/fnana.2022.1099348

FIGURE 2.

FIGURE 2

Early and late-stage rewiring. Early rewiring in 10mo P347L rabbit: (A) 3D rendering of rod bipolar cell (RodBC) dendrites from RPC1. RodBC in blue, cone photoreceptor in pink, rod photoreceptor in purple, and indeterminate in yellow. (B) Pseudocolored TEM image of rod photoreceptor ribbon synapse onto RodBC rendered in panel (A). (C) Pseudocolored TEM image of indeterminate photoreceptor ribbon synapse onto RodBC rendered in panel (A). (D) Pseudocolored TEM image of Cone photoreceptor ribbon synapse onto RodBC rendered in panel (A). Scale bars: 500 nm late rewiring in the pnd 900 RCS rat: (E) TEM image of microneuroma extended over a blood vessel invading inner nuclear layer. (F) GABA, Glycine, and Glutamate channels overlayed on top of the region outlined with a box in panel (E). (G) Higher resolution image of region highlighted with box in panel (F). (H) Pseudocolored high-resolution image of area indicated with arrow in panel (G). Arrows indicate edges of gap junction found intact within microneuroma.