Table 1.
Summary of the five H5N1 infection cases examined in this study
| Case | Date of admission (month, year) | Age (year)/sex | Duration of illness (days) | Day of admission | Sample examined | Lung histology |
Laboratory data (on admission) |
Treatment |
Detection of viral-RNA or antigen |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
qRT-PCR |
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| WBC (/mm3) | Plt (/mm3) | CRP (mg/dl) | Antibiotics | Oseltamivir | MSL | Bronchial aspirate | FFPE lung copies per cell | IHC | ISH | |||||||
| 1 | December, 2003 | 12/F | 8 | Day 6 | Lung | DAD (exudative phase) | 2100 | 45 000 | 3.1 | Yes | No | Yes | + | 256 | + | + |
| 2 | March, 2008 | 11/M | 10 | Day 7 | Lung, liver, heart, kidney, spleen, intestine, pancreas | DAD (exudative phase) | 1700 | 207 000 | 6.8 | Yes | Yes | Yes | + | 4.89 | + | + |
| 3 | December, 2007 | 4/M | 13 | Day 11 | Lung, liver, heart, kidney | DAD (exudative phase) | 2300 | 154 000 | 2.4 | Yes | Yes | Yes | + | 23.1 | + | + |
| 4 | July, 2004 | 4/M | 16 | Day 8 | Lung | DAD (proliferation phase) | 2300 | 150 000 | 0.59 | Yes | Yes | Yes | + | 1.05 | − | − |
| 5 | December, 2003 | 5/M | 18 | Day 8 | Lung | DAD (proliferation phase) | 3400 | 174 000 | 0.59 | Yes | No | Yes | + | UDL | − | − |
Abbreviations: CRP, C-reactive protein; DAD, diffuse alveolar damage; FFPE, formalin-fixed, paraffin-embedded; IHC, immunohistochemistry; ISH, in situ hybridization; MSL, methylpredonisolone(10 mg/kg/day); Plt, Platelet; qRT-PCR, quantitaive real-time RT-PCR; UDL, under detection limit; WBC, white blood cell; +, positive; −, negative.