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. 2022 Dec 22;12:1079569. doi: 10.3389/fcimb.2022.1079569

Table 2.

List of drugs under clinical trials trial against dormant M.tb.

Drug Target Developmental stage Ref
CPZEN-45 WecA enzyme Late-stage pre-clinical development (Takahashi et al., 2013; Zhang et al., 2014)
Nitrobenzothiazinone (BTZ-043) DprE1 Ia/IIb stage trial (Ishizaki et al., 2013)
Allylaminomethanone-A, 7-methoxy-2-naphthol MenA Lead identification stage (Makarov et al., 2009)
Salicylanilide esters ICL Not entered clinical trial (Shetye et al., 2020)
HC106A DosRST Hit identification stage (Lee et al., 2015)
PDKA analogues Malate synthase Hit identification stage (Zheng et al., 2017)
(3-(3,4-Dichlorophenyl) ureido) benzoic acid Cysteine synthase Hit identification stage (Schnell et al., 2015)
4-methoxy-2-(pyridin-4-yl) thiazole-5-carboxylic acid Lysine ϵ-Aminotransferase (LAT) Hit identification stage (Betts et al., 2002)