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. 2022 Dec 26;24:263–312. doi: 10.1016/j.bioactmat.2022.12.014

Fig. 11.

Fig. 11

Lipid, triblock copolymers and dendrimer-based nanocarriers for osteoarthritis therapy. A) Phase behavior of celecoxib-loaded PCLA-PEG-PCLA systems of 25% wt in PBS buffer pH 7.4. (i) Temperature-dependent storage modulus G′ of systems containing different celecoxib loadings (n = 3). (ii) Thickness of both the medial and lateral tibial plateau of the different groups. (iii) EPIC-μCT and Saf-O images of the three different groups [120]. The images reproduced with the permission from Elsevier Ltd. B) Design and synthesis of bioactive PEGylated dendrimer–IGF-1 conjugates as cartilage penetrating nanocarriers. (iv) PEGylated dendrimer nanocarriers extend joint residence and cartilage penetration of IGF-1 in rats. (v) Dendrimer-IGF-1 conjugate reduces cartilage degeneration 4 weeks after surgical traumatic joint injury. (vi) Dendrimer-IGF-1 conjugate reduces osteophyte burden in surgically injured rats 4 weeks after surgery [121]. The images reproduced with the permission from American Association for the Advancement of Science.