Fig. 19.

Nanomaterials with antioxidant property for RA treatment. A) Schematic illustration of NO-Scv Gel-mediated anti-inflammation therapy for treating RA [204]. The image reproduced with the permission from American Chemical Society. B) Polymeric aggregate-embodied hybrid nitric oxide-scavenging “click” hydrogel for combinatorial treatment of rheumatoid arthritis. (i) Representative hind paw images of the sample-treated RA mice [205]. The images reproduced with the permission from Wiley-VCH GmbH. C) Schematic diagram of synthesis, treatment, and brief function mechanism of NG/MTX in treatment of CIA [206]. The image reproduced with the permission from American Chemical Society. D) Schematic representation of valence states recycling in nanoceria and enzymatic modes of nanoceria. (ii) Albumin-binding receptors interaction with A-nanoceria within inflamed RA joint [207]. The images reproduced with the permission from IVYSPRING.