Fig. 21.

Nanomaterials for gene-based therapy of OP. A) Osteoblast-targeting-peptide modified nanoparticle for siRNA/microRNA delivery [213]. The image reproduced with the permission from American Chemical Society. B) Schematic diagrams illustrating the preparation of (DSS)₆-liposome-siRNA. (i) In vivo microCT examination of the three-dimensional trabecular architecture in OVX-treated rats [226]. The images reproduced with the permission from Nature America, lnc. C) Preparation of CH6-LNPs-siRNA. (ii) Representative 3D microarchitecture of the proximal tibia in each group (n = 9), obtained by in vivo microCT examination. (iii) Bone formation examined by sequential labeling with fluorescent dye in non-decalcified bone sections [227]. The images reproduced with the permission from Nature America, lnc.