Fig. 24.

Nanomaterials-based scaffolds for OS therapy and bone tissue engineering. A) Schematic illustration of the fabrication process for BP-BG scaffold and the stepwise therapeutic strategy for the elimination of osteosarcoma followed by osteogenesis using BP-BG [270]. The image reproduced with the permission from WILEY-VCH. B) Schematic diagram for investigation on the integrative treatment of anti-tumor/bone repairing with 3D printing BGM scaffolds. (i) Scheme of fabrication the integrative anti-tumor/bone repair BGM scaffolds [272]. The images reproduced with the permission from Elsevier B.V. C) Schematic illustration of the fabrication of TBGS, ablation of bone cancer, and regeneration of bone tissue [275]. The image reproduced with the permission from WILEY-VCH. D) Ordered arrangement of hydrated GdPO₄ nanorods in magnetic chitosan matrix promotes tumor photothermal therapy and bone regeneration against breast cancer bone metastases. (ii) Micro-CT images of calvarial defects repair model at 3 months after surgery [276]. The images reproduced with the permission from Elsevier B.V. E) Schematic illustration of the fabrication and biomedical applications of DTC@BG scaffolds [39]. The image reproduced with the permission from WILEY-VCH.