Table 2.
Comparison of Jarlsberg and Camembert cheese in development of osteocalcin variables and bone markers and the vitamin K2 vitamers during 6 weeks of daily cheese intake. The results are expressed by mean values with SD in bracket and 95% CIs
| Variables | Baseline | Week 6 | Week 6—baseline | P values between groups | |||
| Jarlsberg (n=41) | Camembert (n=25) |
Jarlsberg (n=41) |
Camembert (n=25) |
Jarlsberg (n=41) |
Camembert (n=25) |
||
| cOC=carboxylated osteocalcin (ng/mL) |
11.2 (9.0) | 16.1 (18.3) | 15.3 (9.5) | 14.9 (15.0) | 4.1 (6.8) | −1.2 (9.7) | p<0.01 |
| 8.4 to 14.1 | 8.6 to 23.7 | 12.3 to 18.3 | 8.7 to 21.0 | 2.0 to 6.2 | −5.3 to 2.8 | ||
| ucOC=undercarboxylated osteocalcin (ng/mL) | 10.2 (10.4) | 7.2 (5.4) | 10.3 (12.9) | 6.6 (5.0) | 0.2 (6.0) | −0.6 (1.9) | p=0.47 |
| 6.9 to 13.5 | 5.0 to 9.4 | 6.3 to 14.4 | 4.5 to 8.6 | −1.7 to 2.1 | −1.4 to 0.2 | ||
| RO =carboxylated/ undercarboxylated |
1.47 (0.94) | 1.86 (1.14) | 2.19 (1.31) | 2.09 (1.34) | 0.72 (0.90) | 0.23 (1.09) | p=0.03 |
| 1.17 to 1.76 | 1.39 to 2.33 | 1.78 to 2.60 | 1.54 to 2.64 | 0.44 to 1.01 | −0.26 to 0.65 | ||
| PINP=procollagen (ng/mL) | 61.1 (27.5) | 61.4 (24.1)* | 69.1 (34.9) | 58.4 (21.7) | 8.1 (13.9) | −1.3 (11.4)* | p<0.01 |
| 52.4 to 69.7 | 51.0 to 71.8 | 58.1 to 80.2 | 49.4 to 67.4 | 3.7 to 12.4 | −6.2 to 3.6 | ||
| CTX=collagen I (ng/mL) | 0.29 (0.13) | 0.27 (0.17)* | 0.27 (0.15) | 0.28 (0.15) | −0.02 (0.13) | 0.02 (0.15)* | p=0.27 |
| 0.25 to 0.33 | 0.19 to 0.34 | 0.22 to 0.32 | 0.22 to 0.34 | −0.06 to 0.02 | −0.04 to 0.08 | ||
| MK-7 (ng/mL) |
0.12 (0.07) | 0.21 (0.17) | 0.15 (0.06) | 0.18 (0.08) | 0.04 (0.07) | −0.03 (0.15) | p=0.02 |
| 0.09 to 0.14 | 0.14 to 0.28 | 0.14 to 0.17 | 0.15 to 0.22 | 0.02 to 0.06 | −0.09 to 0.04 | ||
| MK-8 (ng/mL) |
0.09 (0.07) | 0.12 (0.08) | 0.22 (0.11) | 0.07 (0.06) | 0.12 (0.10) | −0.05 (0.06) | p<0.01 |
| 0.07 to 0.12 | 0.09 to 0.15 | 0.18 to 0.25 | 0.04 to 0.09 | 0.09 to 0.16 | −0.08 to 0.03 | ||
| MK-9 (ng/mL) |
0.09 (0.09) | 0.11 (0.07) | 0.21 (0.09) | 0.05 (0.04) | 0.12 (0.11) | −0.06 (0.07) | p<0.01 |
| 0.06 to 0.12 | 0.08 to 0.14 | 0.18 to 0.24 | 0.04 to 0.07 | 0.09 to 0.16 | −0.09 to −0.03 | ||
| MK-9(4H) (ng/mL) |
0.08 (0.06) | 0.10 (0.07) | 0.14 (0.07) | 0.10 (0.05) | 0.06 (0.05) | 0.00 (0.05) | p<0.01 |
| 0.06 to 0.09 | 0.06 to 0.09 | 0.12 to 0.16 | 0.08 to 0.12 | 0.05 to 0.08 | −0.02 to 0.02 | ||
| 1.15 to 1.26 | 1.11 to 1.26 | 1.18 to 1.29 | 1.10 to 1.22 | −0.02 to 0.09 | −0.08 to 0.03 | ||
*Two baseline blood samples in the Camembert group were lost and reduced the sample to 23 for estimation and comparison of the development in PINP and CTX.
cOC, carboxylation osteocalcin; CTX, C-telopeptide type I collagen; MK, menaquinone; PINP, procollagen type 1 N-terminal propeptide; Ro, osteocalcin ratio; ucOC, undercarboxylated osteocalcin.