Table 2. SE, SP, PPV, and NPV for ruling out the presence of advanced fibrosis/cirrhosis.

Biomarker test and classification	MRE fibrosis stage (‘stage ≥1 to ≤2’ fibrosis or lower vs. ‘stage >2 to <3’ fibrosis or higher)
	SE	SP	PPV	NPV
FIB-4 (advanced fibrosis excluded vs. other)	0.67 (0.53, 0.80)	0.68 (0.60, 0.77)	0.45 (0.34, 0.57)	0.84 (0.77, 0.91)
NFS (F0-2 vs. other)	0.78 (0.67, 0.90)	0.61 (0.53, 0.69)	0.42 (0.32, 0.52)	0.89 (0.83, 0.95)

Confidence intervals are listed in parentheses. SE, sensitivity; SP, specificity; PPV, positive predictive value; NPV, negative predictive value; FIB-4, Fibrosis-4; NFS, NAFLD Fibrosis Score; NAFLD, non-alcoholic fatty liver disease.