Table 3. SE, SP, PPV, and NPV for identifying the presence of advanced fibrosis/cirrhosis.

Biomarker test and classification	MRE fibrosis stage (‘stage ≥3 to <4’ fibrosis or higher vs. ‘stage >2 to <3’ fibrosis or lower)
	SE	SP	PPV	NPV
FIB-4 (advanced fibrosis likely vs. other)	0.51 (0.36, 0.67)	0.91 (0.86, 0.96)	0.63 (0.46, 0.79)	0.86 (0.81, 0.92)
NFS (F3-4 vs. other)	0.55 (0.40, 0.70)	0.94 (0.90, 0.98)	0.72 (0.56, 0.87)	0.88 (0.83, 0.93)

Confidence intervals are listed in parentheses. SE, sensitivity; SP, specificity; PPV, positive predictive value; NPV, negative predictive value; FIB-4, Fibrosis-4; NFS, NAFLD Fibrosis Score; NAFLD, non-alcoholic fatty liver disease.