Table 5. The search strategy summary.

Items	Specification
Date of search	Initial search: 04/23/2020; most recent update: 01/21/2022
Databases	PubMed, Google Scholar
Search terms used	See Table S1
Timeframe	No specific time limitation on publishing date, but recent studies sought
Inclusion and exclusion criteria	Inclusion criteria:
	Biomarkers studied using human blood samples in one of the following: eosinophilic esophagitis; asthma; atopic dermatitis; chronic rhinosinusitis;
	Biological therapies studied in one of the following: eosinophilic esophagitis; asthma; atopic dermatitis; chronic rhinosinusitis
	Exclusion criteria:
	Animal study;
	Biomarker analyzed in tissue or body fluid other than blood;
	No statistical analysis included
Selection process	Initial criteria developed and preliminary search for Table 1 performed by Dr. Rabinowitz. Formal comprehensive searches started by Dr. Yu with updates and modification by Dr. Rabinowitz and Dr. Yu