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. 2022 Dec 26;56:101776. doi: 10.1016/j.eclinm.2022.101776

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© 2022 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 2 — Bridging between PrEP regimens. Plots show data from the HPTN 067 trial. When a model agent is created, a participant from the time-driven arm of HPTN 067 is sampled. That participant has both fixed and on-demand PrEP adherence values (A & E) in quintiles x and y respectively (B & F). For fixed adherence, a participant in the daily PrEP arm with adherence in quintile x is sampled (C & G) and the modeled agent has daily PrEP adherence equal to that participant. For on-demand adherence, a participant in the event-driven PrEP arm with post-sex pill adherence in quintile y is sampled (D & H) and the modeled agent has on-demand PrEP adherence equal to that participant. In this way we use adherence data from the daily and event-driven arms of HPTN 067, linked by actual participants' propensities to adhere to fixed or on-demand pills. Participants may or may not have fixed and on-demand adherence in the same quintile as there was no statistical correlation found between these adherence types.