Table 2.
The role of NLRP3 in chronic kidney disease.
| Disease | Relevant factors change | Animal or cell | role | references |
|---|---|---|---|---|
| Hypertensive nephropathy | IL-1β↑,IL-18↑,ASC↑, Caspase-1↑,NLRP3↑ |
Mice,Glomerular podocyte | Sertoli cell apoptosis,Lysosomal membrane rupture,Renal fibrosis | 60–64 |
| lupus nephritis | NLRP3↑ | Glomerular podocyte | Proteinuria increase | 66 |
| SLE associated nephritis | ASC↑,Caspase-1↑, NLRP3↑ | Mice,Glomerular podocyte | Increase proteinuria | 64 |
| Mesangial proliferative kidney disease | ASC↑,Caspase-1↑, NLRP3↑ | Renal tubular epithelial cell | Renal interstitial inflammation,Renal tubular atrophy | 67 |
| Diabetic nephropathy | IL-1β↓, IL-18↓, ASC↓,Caspase-1↓ | NLRP3−/− mice | decrease inflammation in the kidney | 71–90 |
| Renal ischemia-reperfusion injury | NLRP3↑,ASC↑ | NLRP3−/− mice,Renal tubular epithelial cell | Decrease neutrophilinfiltration | 95–98 |
| Albumin induced nephropathy | NLRP3↑,Caspase-1↑,IL-1β↑,IL-18↑,Cathepsin B↑ | Mice,Renal tubular epithelial cell | Renal tubular cell apoptosis,Lysosome damage | 105 |
| Unilateral ureteral obstruction nephropathy | ASC↑,Caspase-1↑,IL-1β↑,NLRP3↑ | Mice | Renal tubular damage,renal interstitial fibrosis | 69,70 |
| High uric acid nephropathy | NLRP3↑,ASC↑ | Rat,Renal tubular epithelial cell | Renal epithelial-interstitial transformation | 101,103 |
| Azithromycin-treated nephropathy | NLRP3↑, lymphocyte↑ | Rat,Renal tubular epithelial cell | Lymphocyte infiltration | 102 |